• International Journal of Technology (IJTech)
  • Vol 6, No 1 (2015)

Effects of Monocarboxylic Acids and Potassium Persulfate on Preparation of Chitosan Nanoparticles

Effects of Monocarboxylic Acids and Potassium Persulfate on Preparation of Chitosan Nanoparticles

Title: Effects of Monocarboxylic Acids and Potassium Persulfate on Preparation of Chitosan Nanoparticles

Correction for this article:

Corrigendum to: Effects of Monocarboxylic Acids and Potassium Persulfate on Preparation of Chitosan Nanoparticles
Published at: 21 Nov 2024
Eny Kusrini, Ng Sha Shiong, Yosmarina Harahap, Yoki Yulizar, Dianursanti , Rita Arbianti, Aida R. Pudjiastuti

Corresponding email:


Published at : 28 Jan 2015
Volume : IJtech Vol 6, No 1 (2015)
DOI : https://doi.org/10.14716/ijtech.v6i1.778

Cite this article as:
Kusrini, E., Shiong, N.S., Harahap, Y., Yulizar, Y., Dianursanti, Arbianti, R., Pudjiastuti, A.R., 2015. Effects of Monocarboxylic Acids and Potassium Persulfate on Preparation of Chitosan Nanoparticles. International Journal of Technology. Volume 6(1), pp. 11-21

2,430
Downloads
Eny Kusrini Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia
Ng Sha Shiong School of Physics, Universiti Sains Malaysia, Minden, Penang 11800, Malaysia
Yosmarina Harahap Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia
Yoki Yulizar Department of Chemical Sciences, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia
Dianursanti Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia
Rita Arbianti Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia
Aida R. Pudjiastuti Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, 16424, Indonesia
Email to Corresponding Author
Abstract
Effects of Monocarboxylic Acids and Potassium Persulfate on Preparation of Chitosan Nanoparticles

In this research, we studied the preparation of nanochitosan from the addition of potassium persulfate as an initiator for monomer polymerization and monocarboxylic acid—namely acetic acid, lactic acid, and formic acid—to a chitosan solution. To obtain the dried form of chitosan nanoparticles, we investigated the effects of oven and spray drying systems toward the physicochemical properties and morphology of chitosan nanoparticles. Successfully prepared chitosan nanoparticles were characterized by Fourier transform infrared spectroscopy (FTIR), Field Emission Scanning Microscopy/Energy Dispersive X-ray Analysis (FESEM-EDX), and a particle size analyzer (PSA). The structures of nanochitosan prepared in different acids were quite similar based on the FTIR spectra. By increasing the concentrations of potassium persulfate, the yields of chitosan nanoparticles also increased. The concentration of potassium persulfate had a significant influence on the production of chitosan nanoparticles. The lowest concentration of potassium persulfate (0.6 mmol) did not produce an observable formation of chitosan nanoparticles. By using formic acid and potassium persulfate in various concentrations from 1.2–3.0 mmol, chitosan nanoparticles were obtained. A particle size distribution of chitosan nanoparticles was produced from a formic acid solution having a smaller size compared to others. The acidity effect of monocarboxylic acids in the formation of chitosan nanoparticles was better compared to the addition of other acids. Furthermore, synthesized chitosan nanoparticles (50–110 nm) produced from formic acid solutions have potential applications for drug carrier purposes.

Chitosan nanoparticles, Monocarboxylic acid, Oven, Potassium persulfate, Spray drying

References

Agnihotri, S.A., Mallikarjuna, N.N., Aminabhavi, T.M., 2004. Recent Advances on Chitosan-based Micro- and Nanoparticles in Drug Delivery. Journal of Controlled Release. Volume 100(1), pp. 5?28

Al-Remawi, M.M.A., 2012. Properties of Chitosan Nanoparticles Formed using Sulfate Anions as Crosslinking Bridges. American Journal of Applied Sciences, Volume 9(7), pp. 1091?1100

Bodnar, M., Hartmann, J.F., Borbely, J., 2005. Preparation and Characterization of Chitosan-based Nanoparticles. Biomacromolecules, Volume 6, pp. 2521?2527

De Moura, M.R., Aouada, F.A., 2008. Preparation of Chitosan Nanoparticles using Methacrylic Acid. Journal of Colloid and Interface Science, Volume 321(2), pp. 477?483

Dev, A., Binulal, N.S., 2010. Preparation of Poly(lactic acid)/Chitosan Nanoparticles for Anti-HIV Drug Delivery Applications. Carbohydrate Polymers, Volume 80(3), pp. 833?838

Harish Prashanth, K.V., Tharanathan, R.N., 2006. Crosslinked Chitosan-preparation and Characterization. Carbohydrate Research, Volume 341(1), pp. 169?173

Hsu, S.C., Don, T.M., Chiu, W.Y., 2002. Free Radical Degradation of Chitosan with Potassium Persulfate. Polymer Degradation and Stability, Volume 75(1), pp. 73?83

Hu, Y., Jiang, X., 2002. Synthesis and Characterization of Chitosan–poly(acrylic acid) Nanoparticles. Biomaterials, Volume 23(15), pp. 3193?3201

Kusrini, E., Arbianti, R., Sofyan, N., Abdullah, M.A.A., Andriani, F., 2014. Modification of Chitosan by using Samarium for Potential Use in Drug Delivery System. Spectrochimica Acta Part A, Volume 120, pp. 77–83

Kusrini, E., Harahap, Y., Yulizar, Y., Arbianti, R., Dianursanti, Shiong, N.S., 2012. Preparasi dan Karakterisasi Nanopartikel Kitosan dengan Asam Laktat, In Proceeding Seminar Nasional Teknik Kimia (SNTKI), September 20?21 (in Bahasa)

Ravi Kumar, M.N.V., 2000. A Review of Chitin and Chitosan Applications. Reactive and Functional Polymers, Volume 46(1), pp. 1?27

Ravi Kumar, M.N.V., Muzzarelli, R.A.A., Muzzarelli, C., Sashiwa, H., Domb, A.J., 2004. Chitosan Chemistry and Pharmaceutical Perspectives. Chemical Reviews, Volume 104, pp. 6017–6084

Yang, H.C., Wang, W.H., Huang, K.S., Hon, M.H., 2010. Preparation and Application of Nanochitosan to Finishing Treatment with Anti-microbial and Anti-shrinking Properties. Carbohydrate Polymers, Volume 79, pp. 176–179

Download PDF
Who cite this paper
Table of Contents
Article
Abstract
References