Mathematical Model Controlled Potassium Chloride Release Systems from Chitosan Microspheres
Corresponding email: muharam@che.ui.ac.id
Published at : 30 Dec 2015
Volume : IJtech
Vol 6, No 7 (2015)
DOI : https://doi.org/10.14716/ijtech.v6i7.1847
Muharam, Y., Purwanto, W.W., Mulia, K., Wulan, P.P., Marzuki, I., Dewi, M.N., 2015. Mathematical Model Controlled Potassium Chloride Release Systems from Chitosan Microspheres. International Journal of Technology. Volume 6(7), pp. 1228-1237
| Yuswan Muharam | Department of Chemical Engineering, Faculty of Engineering, University of Indonesia, Kampus UI Depok, Depok 16424, Indonesia |
| Widodo Wahyu Purwanto | Department of Chemical Engineering, Faculty of Engineering, University of Indonesia, Kampus UI Depok, Depok 16424, Indonesia |
| Kamarza Mulia | Department of Chemical Engineering, Faculty of Engineering, University of Indonesia, Kampus UI Depok, Depok 16424, Indonesia |
| Praswasti PDK Wulan | Department of Chemical Engineering, Faculty of Engineering, University of Indonesia, Kampus UI Depok, Depok 16424, Indonesia |
| Ismail Marzuki | Department of Chemical Engineering, Faculty of Engineering, University of Indonesia, Kampus UI Depok, Depok 16424, Indonesia |
| Mubarokah N. Dewi | Department of Chemical Engineering, Faculty of Engineering, University of Indonesia, Kampus UI Depok, Depok 16424, Indonesia |
Chitosan can be prepared in the form of microspheres that serve as a depot for bioactive compounds released in a controlled way to diseased organs. In this study, a mathematical model of potassium chloride release from chitosan microspheres was developed. The model was validated using experimental data. The potassium chloride-loading percentages of 10.01%, 20.84%, and 20.57% were prepared using a cross-linking method. The potassium chloride loading was kept constant at about 20% when the potassium chloride mass in the preparation stage was above 5.024 mg/mL. Experiments and a model calculation of potassium chloride release from the microspheres with a loading of 10.01% and 20.57% were performed. In general, the model reproduces the experimental data. The experiments and the calculation show that during the same period, microspheres containing more potassium chloride release a higher percentage of potassium chloride than do microspheres containing less potassium chloride.
Chitosan, Microspheres, Moldeling controlled drug release system, Simulation
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